Product Description: SM-164 is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains with an IC50 value of 1.39 nM and functions as an extremely potent antagonist of XIAP.
Applications: Cancer-programmed cell death
Formula: C62H84N14O6
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References: [1]Sun H, et al. Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP. J Am Chem Soc. 2007 Dec 12;129(49):15279-94./[2]Lu J, et al. SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res. 2008 Nov 15;68(22):9384-93.
CAS Number: 957135-43-2
Molecular Weight: 1121.42
Compound Purity: 99.49
Research Area: Cancer
Solubility: DMSO : 25 mg/mL (ultrasonic)
Target: Apoptosis;IAP
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