Description: This MAb reacts with a membrane-associated protein present in normal and malignant neuroendocrine tissues including small cell lung cancer (SCLC). It stains neural and a variable number of endocrine tissues and in the lung it reacts preferentially with SCLC and carcinoids. Its epitope is destroyed during formalin fixation. This antibody was categorized during the First International Workshop on Small Cell Lung Cancer Antigens held in London in April 1987. There are two major types of Lung Carcinoma: non-small cell, which accounts for 80% of all cases; and small cell, which accounts for roughly 20% of all lung cancers reported. The lung continues to be a customary place for cancer migration from tumors elsewhere in the body. Treatment depends on the specific cell type of the cancer, level of progression and status of the individual patient.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: MOC-52
Immunogen: Lung Cancer-associated antigen isolated from small cell lung carcinoma-derived cell line
Antibody Reactivity: Small Cell Lung Cancer
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- Souhami RL, Beverly PCL, Bobrow LG. (1987) Antigens of small-cell lung cancer: first international workshop. Lancet 2:325-326. (clone characterization)
- J Clin Oncol (1989) 7(11): 1614-1620. (IHC, frozen)
Entrez Gene ID: Not Known
Expected AB Applications: IHC (frozen) (published for clone)
Z-Antibody Applications: IHC, frozen (published)
Antibody Application Notes: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Immunofluorescence: 0.5-1 ug/mL/Immunocytochemistry frozen 0.5-1.0 ug/mL/Optimal dilution for a specific application should be determined by user
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