Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl-2-propen-1-one
Purity: ≥98%
Formula Markup: C15H11BrClNO
Formula Weight: 336.613
CAS Number: 433234-16-3
Notes: An inhibitor of the TRAF6-CD40 protein-protein interaction; binds to TRAF1, TRAF2, TRAF3, and TRAF6 (Kds = 52, 30, 37, and 59 µM, respectively); inhibits LPS-induced increases in the levels of NF-κB in RAW 264.7 macrophages (IC50 = 0.3 µM); inhibits anti-Cd40 antibody-induced increases in the levels of Il-1β and Il-6 in primary mouse bone marrow-derived macrophages (BMDMs; IC50s = 5.7 and 2.4 µM, respectively); increases survival in a mouse model of sepsis induced by cecal ligation and puncture at 10 µmol/kg; decreases blood levels of glucose and adipose tissue levels of leukocytes, Ths, cytotoxic T cells, and M1 and M2 macrophages in a mouse model of DIO at 10 µmol/kg per day
Deutsch
English
