Soticlestat, CAS 1429505-03-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: [2,4'-bipyridin]-3-yl[4-hydroxy-4-(phenylmethyl)-1-piperidinyl]-methanone

Purity: ≥98%

Formula Markup: C23H23N3O2

Formula Weight: 373.44774

CAS Number: 1429505-03-2

Notes: Soticlestat is an inhibitor of cholesterol 24-hydroxylase/CYP46A1 (IC50 = 0.0074 µM).{57814} It is selective for cholesterol 24-hydroxylase/CYP46A1 over the cytochrome P450 (CYP) isoforms CYP2C8, -2C9, -2D6, -3A4, -1A2, and 2C19 (IC50s = 62, 19, >100, 66, >100, and 14 µM, respectively). Soticlestat (0.02% in the diet) reduces seizure frequency and severity and improves survival in a model of Dravet syndrome induced by hyperthermia in mice with heterozygous deletion of Scn1a (Scn1a+/-), the gene encoding voltage-gated sodium channel 1.1 (Nav1.1).{65144}

• Artikelnummer: CAY34928-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34928-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe