SR 3677, CAS 1072959-67-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide

Purity: ≥95%

Formula Markup: C22H24N4O4

Formula Weight: 408.5

CAS Number: 1072959-67-1

Notes: SR 3677 is a potent, ATP-competitive inhibitor of Rho-associated kinases (ROCKs) that shows greater potency against ROCK2 than ROCK1 in enzyme and cell-based assays (IC50 values are 3 and 56 nM, respectively).{27385} At 3 µM, SR 3677 inhibits only 5 (Akt3, Clk1, Clk2, Clk4, Lats2) out of 353 kinases with greater than 50% inhibition.{27385} SR 3677 is efficacious at inhibiting myosin light chain phosphorylation and increasing aqueous humor outflow in porcine eyes in an ex vivo model of glaucoma treatment.{27385}

• Artikelnummer: CAY16708-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16708-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK