Product Description: SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist[1] with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively[2].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C21H28ClNO2
References: [1]Nisoli E, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes.Mol Pharmacol. 1996 Jan;49(1):7-14./[2]Kanzler SA, et al. Involvement of β3-adrenergic receptors in the control of food intake in rats.Braz J Med Biol Res. 2011 Nov;44(11):1141-7./[3]Bruno G, et al. β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation.Oncogene. 2020 Jan;39(2):368-384./[4]Bexis S, et al. Role of alpha 1- and beta 3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse. Br J Pharmacol. 2009 Sep;158(1):259-66.
CAS Number: 1135278-41-9
Molecular Weight: 361.91
Compound Purity: 99.87
Research Area: Metabolic Disease; Cardiovascular Disease
Solubility: DMSO : 250 mg/mL (ultrasonic)/H2O : 2.5 mg/mL (ultrasonic)
Target: Adrenergic Receptor
Deutsch
English
