Product Description: SRD5A1-IN-1 (Compound 4) is a competitive and covalent steroid 5α-reductase type 1 (SRD5A1) inhibitor with an IC50 of 1.44 µM. SRD5A1-IN-1 modulates SRD5A1 function, leading to a lower level of dihydrotestosterone (DHT) production and SRD5A1 protein suppression[1].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C17H11F6NO3
References: [1]Lin A C K, et al. Caffeic acid N-[3, 5-bis (trifluoromethyl) phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics. Scientific Reports, 2022, 12(1): 1-20.
CAS Number: 2279077-93-7
Molecular Weight: 391.26
Compound Purity: 99.82
Research Area: Endocrinology
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: 5 alpha Reductase;Others