Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide
Purity: ≥95%
Formula Markup: C18H18F3N3O
Formula Weight: 349.4
CAS Number: 218156-96-8
Notes: Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-rich splicing factor 1, SRSF1.{27537} SRPIN340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 µM).{27539} It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4.{27539} SRPIN340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells.{27539,27538} By blocking SRPK1-mediated phosphorylation of SRSF1, SRPIN340 modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals.{27543,27541,27540}
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