Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide 3-pyridinecarboxylic acid
Purity: ≥95%
Formula Markup: C16H11N3O3
Formula Weight: 293.3
CAS Number: 285986-31-4
Notes: Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors.{19346,19347,5047} STAT5, which consists of two isoforms STAT5α and STAT5β, is known to be overactive in several kinds of leukemias and various solid tumors. STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that suppresses STAT5 by targeting its SH2 domain (IC50 = 47 µM against STAT5β SH2 domain EPO peptide binding activity).{25879} Comparatively, this compound exhibits reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC50 > 500 µM).{25879} STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts.{25879}
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