Staurosporine , CAS 62996-74-1

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Biological Activity: Staurosporine, a microbial alkaloid with antifungal activity, has been shown to inhibit a variety of kinases including PKA (Ki=7.0 nM), PKG (Ki=8.5 nM), MLCK (Ki=1.3 nM), PKC (Ki=0.7 nM), CaMK (IC50=20 nM), CAMKII (Ki=20nM), tyrosine kinases (IC50=70 nM) and phosphorylase kinase (IC50=0.5 nM).

CAS Number: 62996-74-1

Description: Staurosporine is a potent inhibitor of many kinases including protein kinase C, protein kinase A, and protein kinase G. It also induces apoptosis in human neuroblastoma cell lines and chick embryonic neurons.

Format: Light yellow crystalline solid or solid film at bottom of vial.

Purity: ≥95% by HPLC.

Solubility: Soluble in DMSO or ethanol; insoluble in water.

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Biosafety Level: Not applicable (BSL-1)

References: 1. Matsumoto, H., et al. Biochem. Biophys. Res. Commun. 128: 105-109 (1989)
2. Tamaoki, T., et al. Biochem. Biophys. Res. Commun. 135: 397-402 (1986)
3. Boix, J., et al. Neuropharmacology 36: 811-821 (1997)

• Artikelnummer: BPS27002
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27002
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK