STF-118804, CAS 894187-61-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[5-methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)-benzamide

Purity: ≥95%

Formula Markup: C25H23N3O4S

Formula Weight: 461.5

CAS Number: 894187-61-2

Notes: Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase. Cancer cells commonly have an unusually high rate of NAD+ turnover, suggesting that inhibition of Nampt might selectively target cancer cells. STF-118804 is a small molecule inhibitor of Nampt (IC50s = 3-6 nM) that prevents NAD+ synthesis from nicotinamide.{24585} It inhibits the viability of multiple B-cell acute lymphoblastic leukemia (B-ALL) cell lines with nanomolar potency and induces apoptosis in MV4-11 cells.{24585} At 50 mg/kg for 20 days, STF-118804 has been shown to improve survival in an orthotopic xenotransplant model of high-risk ALL in mice.{24585} It has also been shown to target leukemia stem cells.{24585}

• Artikelnummer: CAY15283-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 15283-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK