STING R232 variant (Y240A mutant; human, recombinant)

Shelf life (days): 365.0

Formulation: 50 mM HEPES, pH 8.0, 100 mM sodium chloride, 10% glycerol

Uniprot ID: Q86WV6

Purity: ≥65% estimated by SDS-PAGE

Formula Weight: 0.0

Notes: Stimulator of interferon genes (STING) is a component of the innate immune response that recognizes and binds to cyclic dinucleotides (CDNs), which either originate from bacteria or are signals of intracellular stress, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).{24607,22400,22401,24611,69771} The R232 variant is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.{38697} STING is composed of four transmembrane domains at the N-terminus, a helix α1 domain involved in protein dimerization and ligand sensing, and a cytoplasmic C-terminal domain containing the cyclic dinucleotide-binding domain, as well as the TBK1/IRF1-binding site, TBK1 phosphorylation site, and IRF3 docking site.{69772} Various mutations in STING either reduce or increase its activity or binding affinity.{38697,41598,34537,24612} The tyrosine-to-alanine substitution at position 240 (Y240A) reduces 2'3'-cGAMP binding to STING and prevents activation of the IFN pathway.{24609}

• Artikelnummer: CAY40240-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40240-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Methode: Western Blotting