Streptozotocin, CAS 18883-66-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose

Purity: ≥95% (mixture of isomers)

Formula Markup: C8H15N3O7

Formula Weight: 265.2

CAS Number: 18883-66-4

Notes: Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals.{21671,21669} It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA.{21670,21667} DNA damage induces activation of poly ADP-ribosylation, depletion of cellular NAD+ and ATP, and formation of superoxide radicals, leading to the destruction of beta cells.{21671} The effectiveness of STZ depends on the level of GLUT2 expression, which in turn may be influenced by age, sex, strain, or species.{21669,21668}

• Artikelnummer: CAY13104-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 13104-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK