Shelf life (days): 1460.0
Formulation: A solid
Formal Name: sulfamic acid, 6,7,8,9,10,11-hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl ester
Purity: ≥95%
Formula Markup: C14H15NO5S
Formula Weight: 309.3
CAS Number: 288628-05-7
Notes: STX-64 is a steroid sulfatase inhibitor (IC50 = 0.008 µM in placental microsomes).{57682} It also inhibits carbonic anhydrase II (CAII; IC50 = 0.025 µM).{57685} STX-64 inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 macrophages (IC50s = 85.76 and 0.081 µM, respectively).{57683} It reduces rat liver steroid sulfatase activity when administered at a dose of 1 mg/kg.{57682} STX-64 (2 mg/kg) inhibits estrone sulfate-induced uterine growth and reduces the growth of N-nitroso-N-methylurea-induced, estrone sulfate-maintained mammary tumors in ovariectomized rats.{57684}
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