SU 6668, CAS 252916-29-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid

Purity: ≥98%

Formula Markup: C18H18N2O3

Formula Weight: 310.4

CAS Number: 252916-29-3

Notes: SU 6668 is an inhibitor of the receptor tyrosine kinases PDGFRβ, VEGFR2, and FGFR1 (IC50 = 0.06, 2.4, and 3.0 μM, respectively) but not EGFR (IC50 >100 μM).{21720,21717} Through these actions, SU 6668 suppresses tumor growth, blocks angiogenesis in tumors, and induces apoptosis of tumor vasculature and regression of established tumors.{21718,21716,21719} It also inhibits metastasis in a mouse orthotopic model of melanoma.{21715} SU 6668 also inhibits Aurora kinases B and C (IC50 = 35 and 210 nM, respectively) and may target other kinases.{21738,17331}

• Artikelnummer: CAY13873-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 13873-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK