Sulindac Sulfone, CAS 59864-04-9

Sulindac metabolite

Product Type: Inducer

CAS No.: 59864-04-9

MolecularFormula: C20H17FO4S

Molecular Weight: 372,41

Source: Synthetic

Purity: >98%

Solubility: Soluble to 25 mM in DMSO, 3 mM in ethanol

Appearance: Yellow solid

PubChem CID: 5472495

Scientific Background: Sulindac is a nonsteroidal anti-inflammatory drug that is known to prevent recurrence and reduce colorectal polyps. It is a prodrug that is metabolized to a sulfide and sulfone derivative in vivo. The mechanism of action of both is the selective induction of apoptosis. The anti-inflammatory properties of sulindac are mediated by COX inhibition (1, 2).

References: 1. Frahm S., et al. (2004) Cancer Cell Int. 4:4.2. Piazza G.A., et al. (1997) Cancer Res. 57(12): 2452-2459.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-262-50MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-262-50MG
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK