Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid, hexasodium salt
Purity: ≥98%
Formula Markup: C51H34N6O23S6 / 6Na
Formula Weight: 1429.1
CAS Number: 129-46-4
Notes: Suramin is a polysulfonated naphthylurea with antiviral, antiparasitic, and anticancer activities.{62519} It is negatively charged at physiological pH and therefore binds to various intracellular targets including, but not limited to, ryanodine receptor 1 (IC50 = 4.9 µM), G protein-coupled receptors, P2 purinergic receptors, PDGF, PKC, transferrin, DNA and RNA polymerases, sirtuins, and various cytokines.{62519,23034,23035} It reduces Zika virus infectivity in Vero cells (IC50 = ~2.5-5 µg/ml).{62520} In vivo, suramin induces cell cycle arrest at the G2/M phase and apoptosis in L. donovani promastigotes in vitro and reduces hepatic parasitic burden in a mouse model of L. donovani-induced visceral leishmaniasis.{62521} It also neutralizes the myotoxic effect of basic phospholipase A2 (PLA2) homolog MjTX-I, a Lys49-PLA2 protein from snake venom, in mouse phrenic-diaphragm preparations.{69266} Suramin (60 mg/kg) reduces tumor volume in patient-derived xenograft (PDX) mouse models of malignant mesothelioma.{62522} Formulations containing suramin have been used in the treatment of African sleeping sickness.
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