Product Description: Synta66 is an inhibitor of store-operated calcium entry channel Orai, which forms the pore of the CRAC channel, and used for the research of neurological disease.
Applications: Neuroscience-Neuromodulation
Formula: C20H17FN2O3
References: [1]Molnár T, et al. Store-Operated Calcium Entry in Müller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels. J Neurosci. 2016 Mar 16;36(11):3184-98./[2]van Kruchten R, et al. Antithrombotic potential of blockers of store-operated calcium channels in platelets. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1717-23./[3]Wajdner HE, et al. Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells. Physiol Rep. 2017 Mar;5(5).
CAS Number: 835904-51-3
Molecular Weight: 352.36
Compound Purity: 98.32
Research Area: Neurological Disease
Solubility: DMSO : 77.5 mg/mL (ultrasonic)
Target: CRAC Channel
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