Syrosingopine, CAS 84-36-6

Product Description: Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine[1][2].

Applications: COVID-19-immunoregulation

Formula: C35H42N2O11

References: [1]Benjamin D, et al. Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells. Cell Rep. 2018 Dec 11;25(11):3047-3058.e4. /[2]Lefèvre-Borg F, et al. Role of the sympathetic nervous system in blood pressure maintenance and in the antihypertensive effects of calcium antagonists in spontaneously hypertensive rats. Hypertension. 1988 Apr;11(4):360-70.

CAS Number: 84-36-6

Molecular Weight: 666.71

Compound Purity: 99.30

Research Area: Cancer; Cardiovascular Disease

Solubility: DMSO : 62.5 mg/mL (ultrasonic)

Target: Monocarboxylate Transporter

• Artikelnummer: MEXHY-N4115-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N4115-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK