Shelf life (days): 730.0
Formulation: A 25 µg/ml solution in acetonitrile
Formal Name: (2S,2'R,3'R,4'S,5'S,5a'R,7'S,9a'R)-4'-(acetoxy-13C2)-5a'-((acetoxy-13C2)methyl-13C)-3'-hydroxy-5',8'-di(methyl-13C)-2',3',4',5',5a',6',7',9a'-octahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-7'-yl-2,2',3,3',4',5',5a',6',7',8',9',9a'-13C12 3-(methyl-13C)butanoate-1,2,3,4-13C4
Purity: ≥98%
Formula Markup: [13C]24H34O9
Formula Weight: 490.3
Notes: T-2 toxin-13C24 is intended for use as an internal standard for the quantification of T-2 toxin (Item No. 11444) by GC- or LC-MS. T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium.{20907} It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC50 = 19.47), primary pig alveolar macrophages (PAMs).{20906} In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg).{20907} It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.
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