Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide
Purity: ≥95%
Formula Markup: C19H20N4O3S2
Formula Weight: 416.5
CAS Number: 552309-42-9
Notes: Transmembrane protein 16A (TMEM16A, also known as anoctamin-1) is a calcium-activated chloride channel (CaCC) with roles in transepithelial anion transport and smooth muscle contraction. T16A(inh)-A01 is an aminophenylthiazole that inhibits transient TMEM16A-mediated chloride currents with an IC50 value of ~1 µM.{29772,29768} Its inhibitory effects are independent of voltage and do not prolong the rate of TMEM16A current deactivation.{29768} T16A(inh)-A01 blocks CaCC activity in vascular smooth muscle cells and relaxes mouse and human blood vessels.{29769} It also inhibits the proliferation of pancreatic cancer and squamous carcinoma cells in culture.{29771,29770}
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