Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 7-(6-fluoro-3-pyridinyl)-5H-pyrido[4,3-b]indole
Purity: ≥98%
Formula Markup: C16H10FN3
Formula Weight: 263.3
CAS Number: 1415379-56-4
Notes: A tau-binding agent; selectively binds to recombinant tau (Kd = 0.2 and 16.8 nM for high- and low-affinity tau binding sites) over 83 receptors, transporters, enzymes, and ion channels in a panel but does bind to MAO-A and MAO-B (Kds = 1.6 and 21 nM, respectively); binds to native tau fibrils from patients with Alzheimer’s disease or PSP (Kds = 0.3 nM for both for high-affinity tau binding sites; Kds = 30 and 70 nM, respectively, for low-affinity tau binding sites) but also binds to brain homogenates from patients without a tau-related disease (Kds = 0.6 and 52.5 nM for high- and low-affinity tau binding sites, respectively) due to its off-target binding to MAO-A and MAO-B
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