Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 9-[4-(cyclohexyloxy)phenyl]-3,4- dihydro-7-methyl-pyrazino[2,1-c][1,2,4]thiadiazine, 2,2-dioxide
Purity: ≥98%
Formula Markup: C19H23N3O3S
Formula Weight: 373.47034
CAS Number: 1358751-06-0
Notes: An AMPA receptor positive allosteric modulator; increases glutamate-induced calcium influx in CHO cells expressing human AMPA receptors (EC50 = 3.3 µM); potentiates AMPA receptor-mediated currents in rat primary hippocampal neurons (EC50= 4.4 µM); ameliorates MK-801-induced working memory deficits in the radial arm maze task in rats from 0.1-10 mg/kg; increases DMTS accuracy in cynomolgus monkeys at 0.06 mg/kg