Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[(2S,3S)-1-(2-hydroxy-2-methyl-1-oxopropyl)-2-[(2,3',5'-trifluoro[1,1'-biphenyl]-3-yl)methyl]-3-pyrrolidinyl]-methanesulfonamide
Purity: ≥98%
Formula Markup: C22H25F3N2O4S
Formula Weight: 470.506189
CAS Number: 2274802-95-6
Notes: An orexin receptor 2 agonist; selectively induces calcium mobilization in CHO-K1 cells expressing human OX2R over those expressing OX1R (EC50s = 0.019 and 14 µM, respectively); selective for OX2R over a panel of 106 enzymes, receptors, and ion channels at 10 µM; increases wakefulness time and wakefulness episode duration and inhibits chocolate-induced cataplexy-like episodes during the active phase in a model of narcolepsy using mice with orexin neurons ablated by ataxin-3 expression; increases wakefulness time but does not affect OXA or OXB CSF levels during the sleep phase in cynomolgus monkeys at 10 mg/kg
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