Tal1(BTL73), 1mg/mL

Description: Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product origin: Animal - Mus musculus (mouse)

Conjugate: Purified, BSA-free

Concentration: 1 mg/mL

Storage buffer: PBS, no BSA, no azide

Clone: BTL73

Immunogen: Recombinant human full-length TAL1 protein

Antibody Reactivity: Tal1

References: Note: References for this clone sold by other suppliers may be listed for expected applications.

1. EMBO J (1997) 16:3145-3157. (WB)
2. Br J Haematol (1998) 102: 449-457. (Flow; IHC)
3. Blood (2002) 100(2): 491-500. (WB; IHC, FFPE; EMSA)
4. Oncogene (2011) 30: 1252-1260. (CHiP)

Entrez Gene ID: 6886

Expected AB Applications: IHC (published for clone)/ChiP (published for clone)/EMSA (published for clone)/Flow (intracellular) (published for clone)/IHC (FFPE) (published for clone)

Z-Antibody Applications: CHiP (published)/Flow, intracellular (published)/IHC (published)/IHC, FFPE (published)/EMSA (published)

Antibody Application Notes: ELISA: For coating, order antibody without BSA; Western blot 0.5-1.0 ug/mL; Optimal dilution for a specific application should be determined./Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody

• Artikelnummer: BTMBNUM2852-50
• Hersteller: Biotium
• Hersteller Artikelnummer: BNUM2852-50
• Verpackungseinheit: 50 µl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Flow Cytometry, Immunohistochemistry, Chromatin Immunoprecipitation (ChIP), EMSA
• Isotyp: IgG1 kappa
• Wirt: Mouse
• Konjugat: Unconjugated