Product Description: Taladegib (LY2940680) is an antagonist of the smoothened receptor.
Applications: Cancer-programmed cell death
Formula: C26H24F4N6O
References: [1]Fraveto A, et al, Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures. PLoS One. 2015 Nov 16;10(11):e0142124./[2]Hoch L, et al. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor. FASEB J. 2015 May;29(5):1817-29./[3]Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45(5):237-246.
CAS Number: 1258861-20-9
Molecular Weight: 512.50
Compound Purity: 99.57
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Smo
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