Taminadenant, CAS 1337962-47-6

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 5-bromo-2,6-di-1H-pyrazol-1-yl-4-pyrimidinamine

Purity: ≥98%

Formula Markup: C10H8BrN7

Formula Weight: 306.1

CAS Number: 1337962-47-6

Notes: An adenosine A2A receptor antagonist (Ki = 12 nM); selective for adenosine A2A receptors over adenosine A1-, A2B-, and A3 receptors (Kis = 2,500, 1,000, and 5,000 nM, respectively); increases the levels of IFN-γ secreted by tumor-associated T cells isolated from patient-derived lung tumors at 1 µM when used in combination with an antibody targeting PD-1 or PD-L1; reduces the number of lung nodules in an MCA-205 murine fibrosarcoma model of lung metastasis at 15 mg/kg per day; inhibits haloperidol-induced catalepsy in a rat model of Parkinson's disease motor symptoms at 3, 10, or 30 mg/kg

• Artikelnummer: CAY32799-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 32799-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK