Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 6,7,8,9,10,11-hexahydro-1,6,6-trimethyl-10,11-dioxo-phenanthro[1,2-b]furan-2-sulfonic acid, monosodium salt
Purity: ≥98%
Formula Markup: C19H17O6S / Na
Formula Weight: 396.39045
CAS Number: 69659-80-9
Notes: Tanshinone IIA sulfonate is a derivative of tanshinone IIA (Item No. 14323) and has immunomodulatory activities.{52201,52202} It reduces secretion of IL-6 and IL-8 induced by cigarette smoke extract (CSE) and prevents CSE-induced decreases in cystic fibrosis transmembrane conductance regulator (CFTR) levels in 16HBE human bronchial epithelial cells.{52201} Inhalation of tanshinone IIA sulfonate (5 mg/kg) reduces lung function decline, mucus production, bronchial collagen deposition, and airspace enlargement in a mouse model of CS-induced chronic obstructive pulmonary disease (COPD). Tanshinone IIA sulfonate (15 mg/kg) reduces myocardial necrosis and production of TNF-α and IL-6 in a mouse model of sepsis induced by cecal ligation and puncture (CLP).{52202} It reduces the number of peripheral CD4+ and CD8+ T cells and prolongs allogeneic skin graft survival in a rat transplantation model.{52203}
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