TB5, CAS 948841-07-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (2E)-1-(5-bromo-2-thienyl)-3-[4-(dimethylamino)phenyl]-2-propen-1-one

Purity: ≥98%

Formula Markup: C15H14BrNOS

Formula Weight: 336.2

CAS Number: 948841-07-4

Notes: TB5 is a potent and selective monoamine oxidase B (MAO-B) inhibitor with Ki values of 110 and 1,450 nM for MAO-B and MAO-A, respectively.{41031} It interacts with the catalytic site of human MAO-B in a competitive manner. In an enzyme assay, MAO-B activity increases from 37% to 97% following inhibitor washout, indicating TB5 binding is reversible. TB5 also demonstrates permeability in a parallel artificial membrane permeation assay (PAMPA), a model for the blood-brain barrier, and has minimal cytotoxicity (>84% cell viability) in HepG2 cells at a concentrations up to 25 μM.

• Artikelnummer: CAY22947-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22947-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK