Product Description: Tenofovir alafenamide (GS-7340) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.
Applications: COVID-19-anti-virus
Formula: C21H29N6O5P
Citations: Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02143-18./Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02143-18./J Antimicrob Chemother. 2017 Jun 1;72(6):1731-1740./J Gastroenterol. 2020 Apr;55(4):441-452/J Med Chem. 2024 May 1./Pharmaceutics. 2021, 13(10), 1656./Research Square Print. 2023 Mar 20./Preprints. 2024 Apr 19./Univerzita Karlova v Praz. 2021 Jun.
References: [1]Babusis D, et al. Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340. Mol Pharm. 2013 Feb 4;10(2):459-66./[2]Ruane PJ, et al. Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):449-55.
CAS Number: 379270-37-8
Molecular Weight: 476.47
Compound Purity: 99.92
Research Area: Infection; Cancer
Solubility: DMSO : ≥ 31 mg/mL/H2O : 6.67 mg/mL (ultrasonic)
Target: HIV;Reverse Transcriptase
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