Product Description: Tenofovir Disoproxil (Bis(POC)-PMPA) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
Applications: Neuroscience-Neuromodulation
Formula: C19H30N5O10P
Citations: Department od Analytical Chemistry, Charles University. 2019 Jun./Adv Sci (Weinh). 2024 Aug 19:e2403058./Int J Antimicrob Agents. 2019 Dec;54(6):814-819./J Gastroenterol. 2021 Feb;56(2):168-180./J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692./J Neuroimmune Pharmacol. 2019 Jul 23;10.1007/s11481-019-09862-1./Sci Rep. 2019 Nov 20;9(1):17158.
References: [1]Murphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3)/[2]Musumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018/[3]Wahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098/[4]Menne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8.
CAS Number: 201341-05-1
Molecular Weight: 519.44
Compound Purity: 99.84
Research Area: Cancer
Solubility: DMSO : ≥ 38 mg/mL
Target: HBV;HIV;Reverse Transcriptase
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