Shelf life (days): 180.0
Formulation: A solution in methyl acetate
Formal Name: 5a-hydroxy-7,11-dioxo-2,3,4,5-tetranor-prostan-1,14-dioic acid-16,16,17,17,18,18-d6
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C16H16D6O6
Formula Weight: 316.4
Notes: tetranor-PGDM lactone-d6 contains six deuterium atoms at the 16, 16', 17, 17', 18 and 18' positions. It is intended for use as an internal standard for the quantification of tetranor-PGDM lactone by GC- or LC-mass spectrometry. PGD2 plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle.{580} tetranor-PGDM is an abundant urinary metabolite of PGD2 that is detectable both in human and mouse and, as such, is used as a biomarker of PGD2 biosynthesis.{15162} tetranor-PGDM lactone is a closed form of tetranor-PGDM. The formation of tetranor-PGDM lactone in biological samples has not been evaluated.
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