Product Description: TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors[1].
Applications: Neuroscience-Neuromodulation
Formula: C23H23F3N2O4
References: [1]Jiang J, et al. Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3591-3596./[2]Kang X, et al. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep. 2017 Aug 25;7(1):9459.
CAS Number: 1415716-58-3
Molecular Weight: 448.43
Compound Purity: 99.92
Research Area: Neurological Disease; Endocrinology
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: 5-HT Receptor;Prostaglandin Receptor
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