Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (3R)-N-[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
Purity: ≥95%
Formula Markup: C33H41ClN6O2
Formula Weight: 589.2
CAS Number: 312637-48-2
Notes: A MC4R agonist that is selective over MC1R, MC3R, and MC5R human receptors expressed in CHO cells (IC50s = 1.2, 2,067, 761, and 326 nM, respectively); activates mutant MCR4s, which have been linked to obesity, in HeLa cells expressing the mutant receptors (EC50s = 0.23, 2.60, 39.7, and 43.6 for Wt, R165Q, C271Y, and N97D, respectively); increases the number of penile erections by 92% in a rat ex copula model of penile erection (5 mg/kg, i.v.); inhibits food intake after overnight fast and decreases nocturnal feeding behavior in mice
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