Product Description: THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species[1].
Applications: Neuroscience-Neuromodulation
Formula: C23H21ClN6O3
References: [1]Smith SM, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey. Neuropharmacology. 2013 Jan;64:215-23./[2]Vardigan JD, et al. Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel rhesus model of antipsychotic activity. Psychopharmacology (Berl). 2016 Jul;233(13):2441-50.
CAS Number: 1257051-63-0
Molecular Weight: 464.90
Compound Purity: 98.75
Research Area: Neurological Disease
Solubility: DMSO : 31.25 mg/mL (ultrasonic)
Target: Phosphodiesterase (PDE)
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