Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-benzamide
Purity: ≥98%
Formula Markup: C31H28ClN7O2
Formula Weight: 566.0527
CAS Number: 1604810-84-5
Notes: THZ2 is a Cdk7 inhibitor (IC50 = 13.9 nM) and a derivative of THZ1 (Item No. 9002215).{31733} It is selective for Cdk7 over Cdk1, -2, -5, -8, and -9 (IC50s = 96.9, 222, 134, 6,830, and 194 nM, respectively). THZ2 (0.001-1 nM) reduces proliferation of BT-549, HCC70, and MDA-MB-468 triple-negative breast cancer (TNBC) cells. In vivo, THZ2 (10 mg/kg) reduces tumor volume in an MDA-MB-231 mouse xenograft model. It also reduces tumor weight and volume, as well as the number of lung metastases, in an SJSA-1 osteosarcoma orthotopic mouse xenograft model.{58124}
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