Tiagabine (hydrochloride), CAS 145821-59-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (3R)-1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl]-3-piperidinecarboxylic acid, monohydrochloride

Purity: ≥98%

Formula Markup: C20H25NO2S2 / HCl

Formula Weight: 412.0

CAS Number: 145821-59-6

Notes: Tiagabine is an inhibitor of GABA transporter 1 (GAT-1; IC50 = 49 nM for GAT-1 expressed in CHO cells).{40522} It inhibits seizures induced by DMCM in mice (ED50 = 1.2 mg/kg, i.p.).{40519} Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg, and it acts synergistically with gabapentin (Item No. 10008346) to delay pain responses in mice in the hot plate test.{40520,40521} Formulations containing tiagabine have been used as adjunctive therapies in the treatment of partial seizures.

• Artikelnummer: CAY22926-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22926-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK