TIC10, CAS 1616632-77-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one

Purity: ≥98%

Formula Markup: C24H26N4O

Formula Weight: 386.5

CAS Number: 1616632-77-9

Notes: TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 µM in a p53-independent manner.{28066} It is orally active, stable, and crosses the blood-brain barrier.{28066} The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor FOXO3a.{28066} TIC10 suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice.{28066}

• Artikelnummer: CAY16109-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16109-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK