Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (4S)-10-[[di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C23H17D6N3O5
Formula Weight: 427.4823
CAS Number: 1044904-10-0
Notes: Topotecan-d6 is intended for use as an internal standard for the quantification of topotecan (Item No. 14129) by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Item No. 11694).{21114,21115,22689} Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay.{42991} Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC50s = 33 and 280 nM, respectively).{21114} Formulations containing topotecan have been used in the treatment of small-cell lung cancer.
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