Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4-[(3-chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
Purity: ≥95%
Formula Markup: C21H14ClFN6
Formula Weight: 404.8
CAS Number: 871307-18-5
Notes: Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50 = 0.05 µM).{32782} It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 µM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 µM, respectively). It enhances differentiation induced by 1,25-dihydroxy vitamin D3 (calcitriol; Item No. 71820) in HL-60 and U937 leukemia cells when used at a concentration of 5 µM.{32785} Tpl2 kinase inhibitor (5 µM) inhibits the proliferation of KG-1a leukemia cells.{32784}
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