Target: TRPC5
Conjugate: RPE
Product Type: Monoclonal
Clone Number: N67/15 (Formerly sold as S67-15)
Immunogen: Synthetic peptide amino acids 827-845 of human TrpC5 (also known as short transient receptor potential channel 5, and Htrp5)
Swiss-Prot: Q9UL62
Purification: Protein G Purified
Storage Buffer: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
Concentration: 1 mg/ml
Specificity: Detects ~110kDa.
Cellular Localization: Membrane
Scientific Background: Transient receptor potential cation channel, subfamily C, member 5, also known as TRPC5, is a subtype of the TRPC family of mammalian transient receptor potential ion channels. Homo-multimeric TRPC5 and hetero-multimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin (1). This activation probably plays a role in rheumatoid arthritis. It has also been recently found to be involved in the action on anaesthetics such as chloroform, halothane and propofol (2).
References: 1. Xu S.Z., et al. (2008) Nature 451(7174): 69-72.2. Bahnasi Y.M., et al. (2008) Br J. Pharamcol. 153(7): 1505-1512.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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