Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide
Purity: ≥90%
Formula Markup: C41H43N3O7S
Formula Weight: 721.9
CAS Number: 537049-40-4
Notes: Tubacin is a tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC) 6 (IC50 = 4 nM).{18338} In comparison, it demonstrates at least 300-fold selectivity against all other HDAC isoforms (IC50s range from 1.3-17.3 μM).{18338} Tubacin induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures.{18338} Tubacin inhibition of HDAC6 has been used as a biochemical tool to control microtubule-dependent intracellular trafficking, to manipulate the aggresome formation of misfolded proteins in certain diseases, and to study the dynamics of cellular adhesion.{22754,16624,21803}
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