TUG-891, CAS 1374516-07-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid

Purity: ≥98%

Formula Markup: C23H21FO3

Formula Weight: 364.4

CAS Number: 1374516-07-0

Notes: TUG-891 is an agonist of free fatty acid receptor 4 (FFAR4/GPR120; EC50s = 0.0436 and 0.0169 µM for the human and mouse receptors, respectively).{28006} It is selective for FFAR4 over FFAR1/GPR40 (EC50 = 64.5 µM for the human receptor) and is inactive against FFAR2/GPR43 and FFAR3/GPR41. TUG-891 (1 µM) inhibits lysophosphatidic acid- or EGF-induced proliferation and migration of DU145 and PC3 prostate cancer cells.{63332} It stimulates glucagon-like peptide 1 (GLP-1) release in STC-1 enteroendrocrine cells and glucose uptake in 3T3-L1 adipocytes, as well as inhibits LPS-induced TNF-α release in RAW 264.7 macrophages when used at a concentration of 10 µM.{63333} TUG-891 (20 mg/kg) reduces sleep fragmentation-induced increases in food consumption and epididymal fat mass in mice.{63334}

• Artikelnummer: CAY17035-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 17035-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK