TX1-85-1, CAS 1603845-32-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[5-[1-[4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-phenoxyphenyl]-2-propenamide

Purity: ≥98%

Formula Markup: C32H36N8O3

Formula Weight: 580.7

CAS Number: 1603845-32-4

Notes: TX1-85-1 is an inhibitor of the epidermal growth factor receptor tyrosine kinase ErbB3 (IC50 = 23 nM).{27814} It also binds to ErbB2, Lyn, and several other Src family kinases in a live cell chemical proteomics assay when used at a concentration of 2 µM. TX1-85-1 inhibits phosphorylation of Akt and ERK1/2 in ErbB3-dependent HCC2935 and OVCAR-8 cells when used at concentrations of 5 and 2 µM, respectively. However, it does not inhibit proliferation of ErbB3-dependent PC9 GR4, HCC827 GR8, or OVCAR-8 cells (EC50s = ≥10 µM).

• Artikelnummer: CAY19164-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 19164-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK