Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2,3-bis[amino[(2-aminophenyl)thio]methylene]-butanedinitrile
Purity: ≥98%
Formula Markup: C18H16N6S2
Formula Weight: 380.5
CAS Number: 109511-58-2
Notes: U-0126 is a MEK inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively.{15076} It is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK and it shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3, MKK-4, MKK-6, Cdk2, and Cdk4. However, U-0126 does phosphorylate and activate AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 15 µM in HEK293 cells).{42109} It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).
Deutsch
English
