Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-a-4-pyridinyl-1H-benzimidazole-2-methanol
Purity: ≥95%
Formula Markup: C26H25N5O
Formula Weight: 423.5
CAS Number: 1515888-53-5
Notes: UCB 9260 is a TNF inhibitor.{66480} It binds to trimeric TNF (Kd = 13.8 nM) and selectively increases the thermal stability of the TNF trimer over 10 other TNF superfamily members at 100 µM. UCB 9260 inhibits TNF-induced NF-κB activity in a reporter assay using HEK293 cells and TNF-induced cytotoxicity in L-929 fibroblasts (IC50s = 202 and 116 nM, respectively). In vivo, UCB 9260 (30-300 mg/kg, p.o.) reduces TNF-induced peritoneal neutrophil recruitment in mice. Intraperitoneal administration of UCB 9260 (150 mg/kg) decreases disease severity in a mouse model of collagen antibody-induced arthritis.
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