UMI-77, CAS 518303-20-3

Product Description: UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

Applications: Cancer-programmed cell death

Formula: C18H14BrNO5S2

References: [1]Abulwerdi F, et al. A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther. 2014 Mar;13(3):565-575.

CAS Number: 518303-20-3

Molecular Weight: 468.34

Compound Purity: 99.66

Research Area: Cancer

Solubility: DMSO : ≥ 28 mg/mL

Target: Bcl-2 Family

• Artikelnummer: MEXHY-18628-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-18628-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK