UNC0321, CAS 1238673-32-9

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine

Purity: ≥98%

Formula Markup: C27H45N7O3

Formula Weight: 515.7

CAS Number: 1238673-32-9

Notes: UNC0321 is an inhibitor of the histone methyltransferases G9a and G9a-like protein (GLP; IC50s = 9 and 15 nM, respectively).{18337} It is selective for G9a and GLP over SET domain-containing protein 7 (SET7), SET8, protein arginine methyltransferase 3 (PRMT3), and jumonji domain-containing 2E (JMJD2E; IC50s = >10,000 nM for all). UNC0321 decreases the levels of dimethylated lysine 9 on histone H3 (H3K9me2) in MDA-MB-231 cells (IC50 = 11 µM) without inducing cytotoxicity (EC50 = >40 µM).{19978}

• Artikelnummer: CAY41100-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41100-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK