UNC0646, CAS 1320288-17-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(1-cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine

Purity: ≥95%

Formula Markup: C36H59N7O2

Formula Weight: 621.9

CAS Number: 1320288-17-2

Notes: G9a and G9a-like protein (GLP) are euchromatic histone-lysine methyltransferases (EHMT2 and EHMT1, respectively) that can heterodimerize with each other to methylate several proteins in addition to histone H3. UNC0646 is a potent and selective inhibitor of G9a and GLP activities in vitro (IC50s = 6 and 15 nM, respectively) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 26 nM).{19978} It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases.{19978} UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line.{19978} This compound selectively targets the corepressor function of G9a without affecting its ability to act as a coactivator with glucocorticoid receptor.{25782}

• Artikelnummer: CAY11085-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11085-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK