UNC2025, CAS 1429881-91-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: trans-4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol

Purity: ≥98%

Formula Markup: C28H40N6O

Formula Weight: 476.7

CAS Number: 1429881-91-3

Notes: UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively).{26933} It less potently inhibits Axl and Tyro3 (IC50s = 14 and 17 nM, respectively) and a panel of related kinases.{26933} UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines and inhibits Mer phosphorylation in bone marrow leukemia cells in vivo.{26933} Pharmacokinetic studies suggest that orally administered UNC2025 at 3 mg/kg will suffice to provide 90% inhibition of Mer and Flt3 at 30 min.{26933}

• Artikelnummer: CAY16613-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16613-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK